3/24/2024 0 Comments Dorsal blastoporal lip![]() ![]() One such candidate gene, noggin, is sufficient for rescuing development of irradiated embryos when its mRNA is injected (C). Establishment of cDNA libraries from extracted dorsal lip mRNA identified candidate genes that may be responsible for neural induction. c, Neurogenin expression induction by the graft of the dorsal blastoporal lip on gastrula explant is lost after SB505124 treatment in most cases, but maintained after SU5402 treatment. Injection of extracted mRNA from the dorsal lip into irradiated Xenopus embryos rescued neural induction and overall development demonstrating there is a genetic basis of neural induction (B). Figure 1: Mangold's dorsal lip transplant experiment in Xenopus demonstrated that a transplanted dorsal lip could induce the formation of a double axis in the new host embryo, solidifying the dorsal lip's sufficiency in neural induction (A). Based on the location of the transplanted cells, what effect would you expect on axis. Question: In the image below, the dorsal blastopore lip has been transplanted to the ventral region of a host Xenopus embryo. It is particularly important for its role in neural induction through the default model, where signaling from the dorsal lip protects a region of the epiblast from becoming epidermis, thus allowing it to develop to its default neural tissue. This problem has been solved Youll get a detailed solution from a subject matter expert that helps you learn core concepts. The dorsal lip is formed during early gastrulation as folding of tissue along the involuting marginal zone of the blastocoel forms an opening known as the blastopore. The dorsal lip of the blastopore is a structure that forms during early embryonic development and is important for its role in organizing the germ layers. ![]()
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